Cytometry A: Winners of the 2010 Paper of the Year Award announced

P4L Researchers around Ekaterina I. Galanzha from Saratov State University were awarded a prize for their paper: In Vivo Multispectral, Multiparameter, Photoacoustic Lymph Flow Cytometry With Natural Cell Focusing, Label-free Detection, and Multicolor Nanoparticle Probes. The award, presented at the CYTO 2010, Seattle, Washington, recognized their article as the best paper to be published during 2008 in the journal Cytometry A.

The publication describes how using the principles of flow cytometry can develop invivo lymph tests. Counting melanoma and immune-related cells in normal, apoptotic, and necrotic stages in lymphatics invivo was demonstrated to have the unprecedented sensitivity as one metastatic cell among millions of normal cells. The time-resolved PA spectral identification of flowing cells was achieved using multicolor labels and laser pulses of different wavelengths and time delays.

Multispectral, noninvasive, portable flow cytometry can be used for preclinical studies on animals with the potential of translation to humans for in vivo PA mapping of colorless lymph vessels and sentinel nodes with simultaneous single cell detection and metastasis assessment without labeling or use of contrast dyes and/or novel low-toxic multicolor probes with different absorption spectra.