nEUROPt "Non-invasive imaging of brain function and disease by pulsed near infrared light"

Contributed by

Rinaldo Cubeddu

Authors

Rinaldo Cubeddu

Abstract

nEUROPt "Non-invasive imaging of brain function and disease by pulsed near infrared light" G.A. 201076 The Project aims at the development and clinical validation of advanced non-invasive optical methodologies for in-vivo diagnosis, monitoring, and prognosis of major neurological diseases (stroke, epilepsy, ischemia), based on diffuse optical imaging by pulsed near infrared light. Established diagnostic imaging modalities (e.g. X-ray Computed Tomography, Magnetic Resonance Imaging, Positron Emission Tomography) provide 3D anatomical, functional or pathological information with spatial resolution in the millimetre range. However, these methods cannot be applied continuously or at the bedside. Diffuse optical imaging is expected to provide a valuable complementing tool to assess perfusion and blood oxygenation in brain tissue and their time evolution in a continuous or quasi-continuous manner, with portable and comparably inexpensive devices in adult and newborn. Recording of diffuse reflectance and/or transmittance of tissue with picosecond time resolution provides information superior to that accessible by using continuous or modulated light and allows for quantification of absorption and scattering properties of various compartments of the head. The participants of the proposed project foresee major developments in technology and data analysis that will enhance time-domain diffuse optical imaging with respect to spatial resolution, sensitivity, robustness of quantification as well as performance of related instruments in clinical diagnosis and monitoring. The diagnostic value of time-domain diffuse optical imaging will be assessed by clinical pilot studies addressing specific neurological disorders, in comparison with established neurophysiological and neuroimaging techniques. Perspectives regarding clinical application of time-domain diffuse optical brain imaging will be estimated and a reliable basis for a potential commercialisation of this novel technique by European medical device manufacturers will be created.

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