P3SENS: Polymer Photonic multiparametric biochemical SENSor for Point of care diagnostics

Contributed by

Domenico Giannone

Authors

Domenico Giannone

Abstract

The detection of chemical or biological substances is increasingly necessary in order to safeguard human or animal health and confront security related problems. The present analytical techniques are expensive and often require highly specialized staff and infrastructures. The fundamental need is to perform screening tests which can be carried out in non-specialised infrastructures, e.g. point of care, schools and public gatherings, before unambiguous identification in a specialised laboratory. Thus there is a need to develop a new detection system that has low-cost and is portable. The system must also offer high sensitivity, selectivity and multi-analyte detection from a sample containing various components (e.g., blood, serum, saliva, urine, etc.). The objective of P3SENS is to design, fabricate and validate a multichannel (50 or more) polymer photonic crystal biosensor for label-free detection of proteins. The disposable biosensor will allow for a “positive/ negative” detection scheme of ultra small concentrations of analytes in solution (< 1 ng/mL). The biosensor will be encapsulated in a specifically designed microfluidic system used for delivering the sample to multiple sensing regions. The design of the biochip will allow it to be easily inserted in a compact measurement platform, usable by non-specialised practitioners outside of specialised laboratories. This will allow simultaneous multi-analyte detection, delivering real-time monitoring, and with an assay duration that will not exceed a few tens of minutes.

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