Laser Spectroscopy Scientist IRC129293

An exciting opportunity exists for a highly-motivated scientist to join a world class team in a collaborative, EPSRC funded, cross-disciplinary project between the Institute of Orthopaedics and Musculoskeletal Science, University College London (UCL) at the Royal National Orthopaedic Hospital, Stanmore Campus and the Central Laser Facility at STFC’s Rutherford Appleton Laboratory in Oxfordshire. The project seeks to develop the application of Raman spectroscopy, namely Spatially Offset Raman Spectroscopy (SORS), for the diagnosis, monitoring and management of skeletal disorders, including osteoarthritis, osteogenesis imperfecta and osteoporosis. The job holder’s main role will be to collect and analyse Raman spectra for assessing the chemical composition of bones, both excised and in-vivo non-invasively. The data analysis will involve chemometric (multi-variant) analysis methods (for example PCA) and then ultimately demonstrating how SORS can be applied in medical studies, including clinical trials on patients. The position is available for one year and will be based principally at the Rutherford Appleton Laboratory. The work will involve interaction and travel between the two sites.

The job requires an organised and highly motivated scientist possessing excellent communication skills with an independent outlook and capable of working in a team delivering to tight deadlines and be prepared to work with human specimens and participate in taking data in the clinical trials. The candidate should hold at least a BSc degree in a natural or engineering discipline and preference will be given to those able to demonstrate a research track record and/or PhD in relevant areas. Experience in lasers, vibrational spectroscopy and multivariate analysis techniques is highly relevant. Programming skills are beneficial but not essential.

(A second position exists for a biomedically oriented researcher with experience in skeletal tissue biology – this position will be based at UCL, Stanmore and is advertised separately through UCL)

Round Robin Experiment

Raman spectroscopy has already proved its effectiveness in many cases for medical diagnostics such as for cancer, cardiovascular diseases and infections. However, there are no standards in the different working groups, e.g. for sample preparation, implementation of the Raman experiments, spectra pre-treatment, data evaluation, etc.In a round robin experiment, the required groundwork will take place in order to define standardised Raman measurement methods, which will be fundamental for establishing Raman spectroscopy for clinical diagnostic procedures.

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